Following a notable advancement in clinical trials, shares of Annovis Bio, Inc. (NYSE: ANVS) have experienced a significant uptick. As of the latest market check today, ANVS stock has surged by 30.32%, reaching a price of $10.53.
Promising Phase III PD Study Results
Buntanetap is safe and effective, according to new findings from Annovis Bio (ANVS) Phase III Parkinson’s Disease (PD) trial. Patients with early-stage Parkinson’s disease have demonstrated improvements in their motor and non-motor activities as well as cognitive abilities after taking the medication.
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Annovis observed improvements in many patients within a short treatment period. These promising results underscore Annovis Bio’s dedication to advancing buntanetap into an extended study. This future study aims to not only confirm the observed symptomatic improvements but also to investigate the drug’s potential disease-modifying properties.
Key Findings and Implications
Significant findings from the study include:
Cognitive Improvements
Buntanetap halted cognitive decline in all enrolled patients (MMSE 20-30) and enhanced cognition in those with mild dementia (MMSE 20-26). In the placebo group, cognition deteriorated throughout the study, whereas all treatment groups maintained their baseline levels, demonstrating a statistically significant effect of the drug in preventing cognitive decline.
Motor and Non-Motor Function
Buntanetap improved motor and non-motor PD-related functions in patients diagnosed for over three years. For patients with a diagnosis longer than three years, the 20mg dose of buntanetap significantly improved scores on the MDS-UPDRS Part II, Part III, Part II+III, and total scores compared to placebo and baseline.
Postural Instability and Gait Difficulty (PIGD)
The disease progresses faster in this group compared to other PD patients. Data indicated that PIGD patients responded better to buntanetap, showing greater improvement than other Parkinson’s patients.
Throughout the study, buntanetap maintained a consistent safety profile across all participants, with no significant differences observed between early and advanced PD patients, reinforcing previous Alzheimer’s disease (AD) data.
